Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: balancing gastrointestinal and cardiovascular risk
نویسندگان
چکیده
منابع مشابه
Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: balancing gastrointestinal and cardiovascular risk
BACKGROUND Differences between gastrointestinal and cardiovascular effects of traditional NSAID or cyclooxygenase-2 selective inhibitor (coxib) are affected by drug, dose, duration, outcome definition, and patient gastrointestinal and cardiovascular risk factors. We calculated the absolute risk for each effect. METHODS We sought studies with large amounts of information to calculate annualise...
متن کاملNonsteroidal anti-Inflammatory drugs and cardiovascular risk.
Nonsteroidal anti-inflammatory drugs (NSAID) inhibit cyclooxygenase (COX) enzymes, which exist in at least two isoforms, COX-1 and COX-2. Aspirin and older agents in this class are nonselective inhibitors of both COX-1 and COX-2. Newer agents termed "coxibs" are selective inhibitors of COX-2. Among the NSAID, only aspirin has been proven to significantly reduce cardiovascular risk, primarily th...
متن کاملNonsteroidal Anti-Inflammatory Drugs and Cardiovascular Risk
electivity toward cyclooxygenase (COX)-2 is usually dened by comparing the capacity of individual nonsteroidal nti-inflammatory drugs (NSAIDs) to inhibit in vitro or ex ivo the generation of thromboxane A2 (TXA2) through OX-1 in aggregating platelets with the capacity to inhibit rostaglandin (PG) E2 generation through COX-2, exressed in leukocytes after an inflammatory stimulus (1). his rather ...
متن کاملNonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors.
OBJECTIVES To analyze selective COX 2 inhibitor nonsteroidal anti-inflammatory drugs (NSAID) in terms of their mechanism of action, principal indications, posology and most common adverse effects. SOURCES MEDLINE and LILACS databases and Food and Drug Administration (FDA) and National Agency for Sanitary Vigilance (ANVISA - Agência Nacional de Vigilância Sanitária) websites. The most importan...
متن کاملGastrointestinal and cardiovascular risks of nonsteroidal anti-inflammatory drugs.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed but can have serious gastrointestinal (GI) and cardiovascular side effects, which have led to the withdrawal of some of these drugs and continuing uncertainty about the best approach to patients requiring NSAID therapy, particularly in those with GI or cardiovascular risk factors. To define the risks to the GI and cardiovascula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Musculoskeletal Disorders
سال: 2007
ISSN: 1471-2474
DOI: 10.1186/1471-2474-8-73